Flow Cytometry Analyzer Supplies
AdipoGen IL-37 hmonomericFc-KIHh
Recombinant Protein. Human IL-37 aa 46-218 Delta5CysS-S and Y85A see reference A. Bujotzek, et al. 2022 is fused at the C-terminus to a Fc human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. IL-37 IL-1F7 IL-1H4 is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells PBMCs and dendritic cells. IL-37 is a soluble and secreted cytokine of 218 residues that shares the beta-trefoil fold common to IL-1 family cytokines. But IL-37 is an atypical member of the IL-1 family of cytokines as it functions to inhibit many of the major pathways of innate and adaptive immunity and inflammation. It binds to the interleukin-18 receptor IL-18R and its co-receptor SIGIRR.
AdipoGen IL-2 SuperkH9T MonoFc-KIHh
Recombinant Protein. The extracellular domain of human IL-2 aa 21-153 mutant H9T containing the mutations of H9 L80F / R81D / L85V / I 86V / I92F and the new mutation Q126T is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta.
AdipoGen IL-2 Superkine FcH9T
Recombinant Protein. The extracellular domain of human IL-2 aa 21-153 mutant H9T containing the mutations of H9 L80F / R81D / L85V / I 86V / I92F and the new mutation Q126T is fused at the C-terminus to the Fc portion of human IgG2. Lyophilized. Contains PBS. Binds to human and mouse IL-2R. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
AdipoGen VSTM5 msFc ms non-lytic
Recombinant protein. The extracellular domain of mouse VSTM5 aa 28-146 is fused to the N-terminus of the mouse Fc IgG2a non-lytic mutant. Source CHO cells. Lyophilized. Contains PBS. The V-set and transmembrane domain-containing protein VSTM family is composed of 8 proteins VSTM1v1, VSTM1v2, VSTM2a, VSTM2b, VSTM2L, VSTM3, VSTM4 and VSTM 5. Members of the VSTM family are associated with the regulation of functions of immune cells, adipose cells and neuronal cells. The VSTM family is an immunoglobulin Ig superfamily that shares structural similarities with the B7-like transmembrane proteins involved in immune regulation. VSTM1 and VSTM4 play positive and negative roles in macrophage activation, respectively. VSTM3 TIGIT acts as a co-inhibitory receptor that suppresses the cytokine production of T cells and NK cells.
AdipoGen IL-2 hSwitch-2monome-KIH
Recombinant protein. The extracellular domain of human IL-2 aa 21-153 mutant pH-resistant Switch-2 containing mutations T37H, R38L, T41S, F42Y, and K43G is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta.
AdipoGen IL-2 SuperkH9T MonoFc-KIHh
Recombinant Protein. The extracellular domain of human IL-2 aa 21-153 mutant H9T containing the mutations of H9 L80F / R81D / L85V / I 86V / I92F and the new mutation Q126T is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta.
AdipoGen IL-2 Superk MonomFc-KIHh
Recombinant Protein. Human IL-2 aa 21-153 mutant H9 containing the mutations L80F / R81D / L85V / I 86V / I92F is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. Interleukin-2 IL-2 is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important homeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
AdipoGen IL-38 aa20-152hmonom-KIH
Recombinant Protein. Human IL-38 aa 20-152 is fused at the C-terminus to the Fc portion of human IgG1 Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Lyophilized. Contains PBS. IL-38 IL-1F10 belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells.
Abcam N-(p-Coumaroyl)serotonin, Antibacterial agent, 25MG
MW 322.36 g/mol, Purity >95%. An antioxidative phenolic naturally found in plants, including safflower seed and millet grain. Inhibits the production of proinflammatory cytokines by LPS-stimulated human blood monocytes. It is believed that this inhibition is a result of the partial down-regulation of cytokine mRNA levels and inhibition of NF-κB activation. Ameliorates atherosclerosis in vivo, reducing lesion area in mice and rabbits. Augments fibroblast proliferation, and promotes relaxation of vascular smooth muscle cells in vitro. Functions as an antioxidant, inhibiting the effects of high glucose-induced cell death, caspase-3 activation, and the overproduction of the mitochondrial superoxide.
The product is subject to the following: Abcam Restricted Use Statement
Abcam N-(p-Coumaroyl)serotonin, Antibacterial agent, 10MG
MW 322.36 g/mol, Purity >95%. An antioxidative phenolic naturally found in plants, including safflower seed and millet grain. Inhibits the production of proinflammatory cytokines by LPS-stimulated human blood monocytes. It is believed that this inhibition is a result of the partial down-regulation of cytokine mRNA levels and inhibition of NF-κB activation. Ameliorates atherosclerosis in vivo, reducing lesion area in mice and rabbits. Augments fibroblast proliferation, and promotes relaxation of vascular smooth muscle cells in vitro. Functions as an antioxidant, inhibiting the effects of high glucose-induced cell death, caspase-3 activation, and the overproduction of the mitochondrial superoxide.
The product is subject to the following: Abcam Restricted Use Statement
